Thesis (Ph.D.) - University of Warwick, 1992.
|Statement||by Michael Stephen Skinner.|
Cytochrome P Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology. The Amazon Book Review Book recommendations, author interviews, editors' picks, and more. 5/5(1). Book, Internet Resource: All Authors / Contributors: P in plants --Cytochrome P in insects --Cytochrome P in unicellular organisms --Extrahepatic microsomal forms: olfactory cytochrome P --Extrahepatic microsomal forms: gastrointestinal cytochromes P The presence ofa very active cytochrome Pdependent drug-metabolizing system in the olfactory epithelium has been confirmed byusing 7-ethoxycoumarin, 7-ethoxyresorufin, hexobarbitone and aniline as substrates, and the reasons for the marked activity ofthe cytochrome P in this tissue have been. The ratio of reductase to cytochrome P was found to be considerably higher in the olfactory epithelium () than in the liver (), regardless of the species examined, suggesting.
About this book. During half a century, cytochrome P in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P enzymes. Cytochrome P enzymes (Ps) are involved in many physiological functions in insects, such as the metabolism of signal molecules, adaptation to host plants and insecticide resistance. Several Ps have been reported in the olfactory organs of insects, the antennae, and have been proposed to play a role in odorant processing and/or. Cytochrome P (CYP) is a super family of phase I enzyme in the biotransformation of xenobiotics and medications. Most medications undergo deactivation by CYP, and then are eliminated through. Cytochrome P enzymes convert aflatoxins to the reactive 8,9-epoxide form (also referred to as aflatoxin-2,3 epoxide in the older literature), which is capable of binding to both DNA and proteins. Mechanistically, it is known that the reactive aflatoxin epoxide binds to the N7 position of guanines.
Olfactory sustentacular cells and Bowman's gland cells in sections posterior to the nasal papilla stained most intensely. Western blot analysis revealed that anti-CYP2A10/11 recognized a sharp band of approximately 50 kDa in nasal respiratory and olfactory microsomes, supporting the premise that the antibody is reacting with a cytochrome P Biochemistry All Publications/Website. OR SEARCH CITATIONS. This book is a comprehensive collection of in-depth reviews on each cytochrome P family, with metabolic and toxicologic implications. The book starts with a historical perspective and provides anecdotes describing the identification of this superfamily of Reviews: 1. Purchase Cytochrome P, Volume - 1st Edition. Print Book & E-Book. ISBN ,